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Inside Blackstone’s long game for Hologic

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Inside Blackstone’s long game for Hologic

Yiwen Lu's avatar
Shubham Saharan's avatar
  1. Yiwen Lu
  2. +Shubham Saharan
  3. + 1 more
6 min read

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Blackstone’s outreach to Hologic CEO Stephen MacMillan last year was not done on a whim.

Since its founding in 1985 and subsequent IPO in 1990, Hologic has established its footprint in mammography and molecular diagnostic testing for women’s health, a field with high barriers to entry.

The Covid pandemic was also a massive financial catalyst for the company. In early 2020, Hologic developed multiple Covid-19 assays and won emergency use authorization for its Aptima SARS-CoV-2 test. In Q1 2021, the company’s diagnostic sales grew to $1.1bn from $312m in the year prior.

But post-Covid, the company grappled with the macro headwinds hitting healthcare companies. By 2024 and 2025, Hologic’s Covid-related revenue had significantly declined over the course of multiple quarters. Despite growth in its core molecular diagnostics portfolio, its total revenue decline did not go unnoticed by Wall Street.

Around the same time, Hologic was severely hit by the global chip shortage, which specifically impacted its breast health segment. That resulted in Hologic cutting its annual revenue forecast twice last year. Then in May 2025, it lowered the annual profit forecast, citing tariffs and geopolitical conditions.

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